Tumor M2-PK Test

The intestinal cancer is the fourth most frequent reason for deaths from cancer globally.

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Tumor M2-PK Test
The intestinal cancer is the fourth most frequent reason for deaths from cancer globally.
If the supporter lesions of the intestinal cancer can be detected at early stages, they are easily treated by removing them under endoscopy. Therefore, development of effective scanning strategies for early diagnosis in intestinal cancers is vital.  

Although colonoscopy is the best method in detecting intestinal cancers, its application in scanning programs is not suitable due to inconveniency and difficulty of the application to patients. Therefore, there is a need for suitable biochemical tumor determinant markers  that may be applied in scanning of patients under a cancer risk.  

The tumor M2-PK (M2-pyruvate kinase), a recently developed new biochemical determinant markers , is very effective in detecting intestinal cancers at an early stage. 
Pyruvate kinase (PK) is an enzyme applied in energy production from sugar. A special type of this enzyme M2-PK plays a role in the course of development of cancer.
How is interconnection between tumor M2-PK and intestinal cancer?
  • Tumor M2-PK levels particularly increase in patients with intestinal cancer significantly.  
  • The tumor M2-PK levels correlate to the sizes of tumors well. 
  • They may be detected at early stages of intestinal cancers.
When to apply the Tumor M2-PK test
  • Scanning of the individuals who are susceptible to intestinal cancer
  • Scanning of the individuals experiencing cancer in their families  
  • Monitoring of aggressiveness of tumor 
  • Tracking of response to treatment of intestinal cancer
  • Early detection of exacerbation 
  • Early detection of metastasis  


  • S. Mazurek, P.D. Hardt, M. Toepler, P. Schlierbach, R.G. Bretzel, E. Eigenbrodt and H.U. Kloer. Poster of the 2. Biebrich İnterdisciplinary Conferance Colon and Rectal Cancer. Wiesbaden-Biebrich/ Germany, 2003
  • F. Hugo, S. Mazurek, P.D. Hardt and E. Eigenbrodt. Ouantitative Detection Tumor M2-PK: Evaluation of Blood and Stool Specimen Stability, National Meeting of the Association of Clinical Biochemistry, Glasgow/US, 2005
  • J. Schneıder, N. Bitterlich and G. Schulze. Improved Sensitivity in the Diagnosis of Gastro-Intestinal Tumors by Fuzzy logic-based tumor Marker Profiles Including the Tumor M2-PK. Anticancer Res. 25: 1507-1516, 2005
  • Y. Kumar, N. Tapuria, N. Kirmani and Brian R. Davidson. Tumor M2-Pyruvate Kinase: A Gastrointestinal Cancer Marker. European J of Gastroenterology&Hepatology. 19: 265-276, 2007
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